Overview of DLBCL diffuse large B-cell lymphoma and MALT Lymphoma (mucosa-associated lymphoid tissue lymphoma ).
All other types are rare in the thyroid.
DLBCL, > 50% MALT (10–23%)
DLBCL More aggressive. MALT Less aggressive.
DLBCL Cytology Large, monotonous lymphoid cells, lymphoepitheliallesions, decreased or absent colloid.
MALT Cytology Intermediate-sized cells, lymphoepithelial lesions, reactive lymphoid follicles,plasma cell component.
Radiation and chemotherapy.
Localized, radiation 5-y disease-specificsurvival rates (96–100%).
Disseminated, radiation chemotherapy 5-y disease-specificsurvival rates ( 71–75%).
Thyroid Lymphoma Staging
I E no spread outside the thyroid gland.
II E Local lymph nodes
III E Lymph node on both sides of the diaphram.
VI E Diffuse disease
This is a rare cancer occurring in CHT.
Papillary thyroid cancer is common and the main cancer occurring in CHT.
Thyroid Lymphoma is very rare, but when it happens it is usually in a patient with long standing stable CHT with an enlarged thyroid goiter. This changes one day when the patient notices the thyroid gland is enlarging over a short period of time.
Patients with CHT have a 70-89 times higher chance of getting a thyroid lymphoma compared to normal patients without CHT.
It takes 20-30 years after the onset of CHT to develop thyroid lymphoma.
A thyroid consultation can determine if you have a thyroid lymphoma by neck exam,ultrasound biopsy and flow cytometry.
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